|
KMID : 0545120170270101892
|
|
Journal of Microbiology and Biotechnology
2017 Volume.27 No. 10 p.1892 ~ p.1895
|
|
|
Recombinant Adeno-Associated Virus Expressing Truncated IK Cytokine Diminishes the Symptoms of Inflammatory Arthritis
|
|
Choi Seul-Gi
Park Hye-Lim
Minelko Marstella
Kim Eun-Kyung
Cho Mi-Ra
Nam Jae-Hwan
|
|
|
Abstract
|
|
|
|
IK can downregulate interferon-gamma-induced major histocompatibility complex (MHC) class II expression through the MHC class II transactivator, which suggests that IK can inhibit the interactions between immune cells. We delivered adeno-associated virus serotype 2 (AAV2) encoding the genes for truncated IK (tIK) or green fluorescent protein (GFP) to DBA1/J mice via intravenous injection. Seven weeks after injection, collagen-induced arthritis was induced in the AAV2-treated mice. AAV2-tIK injection reduced the severity of arthritis and the percentage of pathogenic Th17 cells compared with AAV2-GFP injection. These results suggest a novel gene therapy strategy for treatment of inflammatory arthritis.
|
|
|
KEYWORD
|
|
|
Adeno-associated virus, Gene therapy, inflammatory arthritis, rheumatoid arthritis, truncated IK
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|